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Platforms and Capabilities

Capillary Electophoresis

Kashi Clinical Laboratories is an independent CLIA-approved lab for capillary electrophoresis. Using the U.S. Food and Drug Administration-3500xl Dx Sanger sequencing platform to detect and identify fluorescence-labeled DNA, Kashi offers precise capillary electrophoresis. Standard four-color fluorescent labeling, where each color represents one of the four DNA bases, is widely recognized as the preferred detection method for automated capillary electrophoresis platforms. Using capillary electrophoresis, Kashi's scientists can provide you with faster results and high-resolution separation.

3500xlCapillary electrophoresis is an analytical technique that separates ions based on their electrophoretic mobility, with the use of an applied voltage. The electrophoretic mobility is dependent upon the charge and size of the molecule. The rate at which the particle moves is directly proportional to the applied electric field: The greater the field strength, the faster the mobility.

Neutral species are not affected; only ions move with the electric field. If two ions are the same size, the one with greater charge will move the fastest. For ions of the same charge, the smaller particle has less friction and overall faster migration rate.

Kashi offers:

  • In-vitro diagnostics for HLA
  • Fragment analysis (microsatellite analysis) (non FDA use)
  • de novo sequencing and re-sequencing (non FDA)

3500xl Dx specifications:

  • IVD (21CFR) compliant system can be used for data intended for FDA submissions
  • IVD (21CFR) validated system software that provides real-time data collection, security, audit and electronic signature features
  • RFID (radio frequency identification) for tracking key consumables and record administrative information
  • IVD labeled reagents
  • 24-capillary array with thermal system design for demanding DNA fragment analysis